用途 A cell-permeable, selective and irreversible PPARγ antagonist (IC50 = 3.3 nM, 32 nM, and 2 碌M for PPARγ, PPARα, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the bindin g site of PPAR. At a concentration of 10 碌M, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-a (LXRa), retinoic acid recep tor (RAR), retinoid X receptor-a (RXRa) and thyroid receptors a and b (TRa and TRb。